在IL28B的遗传变异和C型肝炎病毒自发清除
David L Thomas1, Chloe L Thio, Maureen P Martin
1Johns Hopkins University, Division of Infectious Diseases, Baltimore, Maryland 21205, USA.
Nature
|September 18, 2009
概括
在IL28B附近的一种特定基因变异强烈影响了身体自然清除C型肝炎病毒 (HCV) 感染的能力. 这种遗传因素是自发HCV清除中发现的最重要的因素.
科学领域:
- 免疫遗传学 免疫遗传学
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
背景情况:
- 型肝炎病毒 (HCV) 感染影响全球数百万人,往往导致慢性肝病.
- 自发病毒清除与宿主免疫反应有关,这表明遗传因素起着作用.
- 一项先前的研究确定了与HCV治疗反应相关的IL28B基因附近的单核酸多态 (rs12979860).
研究的目的:
- 调查rs12979860多态和C型肝炎病毒 (HCV) 自发清除之间的关联.
- 为了确定这种遗传变异是否会在自然历史环境中影响HCV感染的结果.
主要方法:
- 在两个队列中rs12979860单核酸多态的基因定型:自发清除HCV的个体 (n=388) 和持久感染的个体 (n=620).
- 对基因型频率与不同祖先的HCV清除状态的分析.
主要成果:
- 发现rs12979860的C/C基因型显著增强了HCV感染的自然消失.
- 这种强烈的关联在欧洲和非洲祖先队伍中都被观察到.
- 这代表了迄今为止对自发HCV清除发现的最重要的遗传因素.
结论:
- IL28B基因区域,特别是rs12979860多态,在宿主自然清除型肝炎病毒的能力中起着至关重要的作用.
- 这些发现凸显了宿主遗传因素在决定HCV感染结果中的重要性,并暗示了III型干扰素在病毒分辨率中的作用.
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