微粒用于输送氧化
Yun Suk Jo1, André J van der Vlies, Jay Gantz
1Institute of Bioengineering (IBI), Ecole Polytechnique Federale de Lausanne, Lausanne CH 1015, Switzerland.
Journal of the American Chemical Society
|September 22, 2009
概括
新的区块共聚合物通过自组装的细胞在7天内提供氧化 (NO). 这一突破使长期的NO疗法成为可能,针对动脉等复杂组织进行增强治疗.
科学领域:
- 聚合物化学 聚合物化学
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
背景情况:
- 氧化 (NO) 具有治疗潜力,但其半衰期短且不稳定.
- 开发稳定的NO释放系统对于有效的长期NO基疗法至关重要.
- 区块共聚合物为控制释放应用提供了一个多功能平台.
研究的目的:
- 设计和合成用于持续释放氧化 (NO) 的新型区块共聚合物.
- 研究这些共聚合物的自我组装行为,使其成为用于NO封装的微粒.
- 评估开发系统的长期NO释放动力学和组织透能力.
主要方法:
- 一个包含水友性N-烯基基摩尔 (AM) 和水友性前体N-烯基-2,5-二甲基皮佩拉 (AZd) 的块共聚物的合成.
- 化学修改AZd块以形成N-diazeniumdiolate (NONOate) 以产生NO,诱导疏水性.
- 使用动态光散射和体外释放研究等技术,描述细胞形成,NO释放动力学和组织透.
主要成果:
- 成功合成了AM-AZd块共聚合物,形成了ca. 在NONOate形成上的50nm球形菌根.
- 由于NONOate的细胞核心屏蔽,NO释放的半衰期为7天.
- 释放的NO再生了原来的可溶性聚合物,表明可回收系统.
- 含NO的菌体显示出能够透到复杂的生物组织,如动脉介质.
结论:
- 区块共聚物亲氨基和氨基为非常长期的氧化 (NO) 输送提供了一个强大的平台.
- 由NO生成群触发的自我化提供了一种独特的控制释放和增强稳定性的机制.
- 这些不释放NO的微粒对针对具有挑战性的生物环境的基于NO的先进疗法充满希望.
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