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在PARP-1自动修改领域中识别ADP-ribosylation位点:分析和影响

Zhihua Tao1, Peng Gao, Hung-wen Liu

  • 1Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712, USA.

Journal of the American Chemical Society
|September 22, 2009
PubMed
概括

研究人员在Poly(ADP-ribose) 聚合酶-1 (PARP-1) 的D域内确定了三个特定的ADP-ribosylation位点. 这项研究揭示了自动修饰发生在D域之外,并且D域对PARP-1酶活性不必.

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