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Efficient Derivation of Human Neuronal Progenitors and Neurons from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction
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减少神经元分化的奥秘

Bennett G Novitch1, Samantha J Butler

  • 1Department of Neurobiology, Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. bnovitch@ucla.edu

Cell
|September 22, 2009
PubMed
概括

一种涉及GDE2和Prdx1的新型醇-氧还原反应通过调节神经原始细胞周期来促进神经发生. 这一发现澄清了神经系统发育的机制.

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Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
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