慢性冠状动脉疾病中的粒细胞殖民地刺激因子通过冠状动脉附带生长来挽救心肌:一项受控随机试验
Pascal Meier1, Steffen Gloekler, Stefano F de Marchi
1Professor of Medicine and Co-Chairman of Cardiology, University Hospital, CH-3010 Bern, Switzerland.
Circulation
|September 23, 2009
概括
颗粒细胞殖民地刺激因子 (G-CSF) 有效地促进冠状动脉附带生长,改善冠状动脉病患者的心肌挽救. 这项研究证明了G-CSF.
科学领域:
- 心血管医学 心血管医学
- 再生医学是一种再生医学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 颗粒细胞殖民地刺激因子 (G-CSF) 在促进冠状动脉附带生长和随后的心肌救援方面的作用仍未得到研究.
- 冠状动脉疾病需要策略来增强附带循环,以改善心肌的保存.
研究的目的:
- 评估G-CSF在促进慢性稳定冠状动脉疾病患者冠状动脉附带生长和心肌挽救方面的疗效.
- 评估G-CSF对心脏病发作大小和定量附带功能的标记物的影响.
主要方法:
- 一项随机,安慰剂控制,双盲研究,涉及52名冠状动脉疾病患者.
- 患者接受皮下G-CSF (10微克/千克) 或安慰剂两周.
- 评估了附带功能,使用附带流量指数 (CFI) 和冠状动脉气球封闭期间的ST段升高.
主要成果:
- 与安慰剂相比,G-CSF治疗导致ST段升高显著降低,表明心脏病发作大小较小 (21%对0%,P=0.0005).
- 与基线 (0.121至0.166,P<0.0001) 相比,G-CSF显著改善了抵押品流量指数 (CFI).
- 而安慰剂组的CFI没有显著变化 (0.152到0.131,P<0.0001).
结论:
- 皮下G-CSF是有效的短期方案,以提高心肌救援.
- G-CSF促进冠状动脉附带生长,为缺血性心脏病提供潜在的治疗策略.
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