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Updated: May 5, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
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Published on: September 21, 2011

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一个表皮性子限制了葡萄糖皮质体受体进化的方向

Jamie T Bridgham1, Eric A Ortlund, Joseph W Thornton

  • 1Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon 97403, USA.

Nature
|September 26, 2009
PubMed
概括

蛋白质功能的进化变化,如葡萄糖皮质体受体中的激素特异性,可以变得不可逆转. 随后的突变优化了新的功能,但阻止了回归原始状态,突出了蛋白质进化的历史偶然性.

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