抗原检测在预测侵袭性肺阿斯伯吉洛症中的价值
T R Rogers1, K A Haynes, R A Barnes
1Department of Medical Microbiology, Charing Cross and Westminster Medical School, London.
Lancet (London, England)
|November 17, 1990
概括
使用ELISA查中性衰竭患者的阿斯珀吉勒斯抗原有助于早期诊断侵袭性肺阿斯珀吉洛症 (IPA). 这种检测方法可以准确预测IPA的发展,提高患者的生存率.
科学领域:
- 医学真菌学 医学真菌学
- 临床诊断 临床诊断 临床诊断
- 免疫学 免疫学 免疫学
背景情况:
- 侵入性肺阿斯伯吉洛症 (IPA) 是免疫功能低下患者的一种危及生命的感染.
- 早期和准确的IPA诊断对于有效的治疗和改善患者的结果至关重要.
研究的目的:
- 评估两种酶相关免疫吸收试验 (ELISA) 在血清和尿液中检测Aspergillus抗原的实用性.
- 评估抗原检测对中性衰竭患者IPA发展的预测价值.
主要方法:
- 用两个ELISA检测血清和尿液样本中的Aspergillus抗原.
- 研究了121名接受白血病治疗或骨髓移植的严重中性衰竭患者.
- 为IPA检测计算了诊断性能指标,包括预测值.
主要成果:
- 抗原检测在预测IPA发展方面表现出很高的准确性,正负预测值超过95%.
- 在13例临床怀疑的真菌感染病例中的11例中,在临床诊断之前检测到了抗原.
- 在没有证据表明IPA的患者中很少检测到抗原 (90分之一).
结论:
- 基于ELISA的Aspergillus抗原检测是早期诊断中性衰竭患者IPA的一个有价值的工具.
- 该试验能够预测IPA发展的能力支持其在临床决策中的使用.
- 常规查Aspergillus抗原在风险患者建议指导实证抗真菌疗法和改善生存率.
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