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社区生活方式的特点和儿童急性淋巴细胞白血病的风险
F E Alexander1, T J Ricketts, P A McKinney
1Department of Pathology, University of Leeds, UK.
Lancet (London, England)
|December 15, 1990
概括
儿童白血病的发病率在偏远地区更高,特别是在富裕社区的幼儿中. 这表明儿童急性淋巴细胞白血病 (ALL) 的潜在感染原因.
科学领域:
- 流行病学 流行病学
- 儿科瘤学 儿科瘤学
- 环境健康 环境健康
背景情况:
- 儿童白血病发病率升高与社区隔离和人口变化有关.
- 了解地理和社会经济因素对于儿童癌症研究至关重要.
研究的目的:
- 研究地理隔离与儿童急性淋巴细胞白血病 (ALL) 发病率之间的关联.
- 探索儿童ALL的社会经济和特定年龄的风险因素.
主要方法:
- 利用来自英格兰和威尔士两个专门的癌症登记处的发病率数据.
- 病房级别的白血病率与人口普查和军火调查数据相关联.
- 基于城市中心的邻近,社会经济地位和年龄组分析风险.
主要成果:
- 在距离大型城市中心最远的病房中观察到儿童ALL风险增加.
- 这种过度风险在社会经济地位较高的病房中更为明显.
- 在1至7岁的儿童中发现了两倍的过度风险,这是ALL的典型高峰年龄.
结论:
- 这些发现支持了儿童白血病感染性病因的假设.
- 地理隔离和社会经济因素可能在儿童ALL风险中起作用.
- 进一步研究儿童ALL的环境和传染性触发因素是有必要的.
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