核糖体蛋白S6激酶1信号调节哺乳动物的寿命

Colin Selman1, Jennifer M A Tullet, Daniela Wieser

  • 1Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK.

Science (New York, N.Y.)
|October 3, 2009
PubMed
概括

在小鼠中删除核糖体S6蛋白激酶1 (S6K1) 延长了寿命和改善了健康期,模仿了卡路里限制的影响. 这表明S6K1和AMPK的操纵可以提供对衰老疾病的保护.

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