流血增加了患有外周动脉疾病的患者缺血事件的风险
相关实验视频
Updated: Jan 9, 2026
01:19
Regulation of Hormone Secretion
6.0K
Eline S van Hattum1, Ale Algra, James A Lawson
1Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, the Netherlands. e.vanhattum@umcutrecht.nl
Circulation
|October 7, 2009
概括
严重出血显著增加了周围动脉疾病患者随后缺血事件的风险. 这一发现强调了在使用抗血栓治疗时仔细管理出血风险的必要性.
科学领域:
- 心血管医学 心血管医学
- 血管外科 血管外科
- 血栓形成的研究研究
背景情况:
- 周围动脉疾病 (PAD) 患者面临高缺血事件风险,需要抗血栓治疗.
- 冠状动脉疾病和脑血管疾病中的出血并发症与随后的缺血事件有关.
- 在PAD中,出血和缺血事件之间的关系需要进行调查.
研究的目的:
- 确定主要出血是否预测了外周动脉疾病患者随后的缺血事件.
- 评估PAD中主要出血和主要缺血并发症之间的独立关联.
主要方法:
- 来自荷兰绕道和口服抗凝剂或阿司匹林 (BOA) 研究的数据分析,这是一个随机试验.
- 包括2650名接受了下 inguinal 绕道手术的患者.
- 多变量考克斯回归模型用于计算主要出血的危险比率,作为主要结果事件 (非致命心肌梗塞,缺血性中风,主要截肢,心血管死亡的复合) 的预测指标.
主要成果:
- 在平均14个月的随访期间,2650名患者中发生了101次非致命性重大出血.
- 大型出血独立地与随后缺血事件的风险增加3倍相关 (调整后的危险比率3.0).
- 大型出血和随后的主要结局事件之间的平均时间为4个月.
结论:
- 大型出血是外周动脉疾病患者主要缺血并发症的独立预测因素.
- 这些发现与冠状动脉疾病和脑血管疾病患者群体的观察结果一致.
- 临床实践应强调在服用抗血栓剂的PAD患者中对重大出血风险的谨慎.
相关概念视频
Regulation of Hormone Secretion
6.0K
Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
Humoral...
6.0K
Hormonal Regulation
47.7K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
47.7K
Overview of Secretory Vesicles
9.3K
Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
9.3K
Insulin Secretory Vesicles
6.3K
Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
6.3K
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
2.1K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
Insulin and C-peptide are...
2.1K
Feedback Inhibition
56.8K
Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
56.8K