在加拿大,患有2009年流感A (H1N1) 感染的重症患者
Anand Kumar1, Ryan Zarychanski, Ruxandra Pinto
1Section of Critical Care Medicine, Health Sciences Centre, JJ 399, 700 William Ave, Winnipeg, MB R3E-0Z3 Canada. akumar61@yahoo.com
JAMA
|October 14, 2009
概括
加拿大2009年流感A(H1N1) 严重病情的患者经历了疾病的快速进展,严重的低氧化和器官衰竭. 结果包括长时间的机械通风和显著的死亡率,突出了重症监护的必要性.
科学领域:
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
- 流行病学 流行病学
背景情况:
- 2009年流感A(H1N1) 流行病在北美出现了大量病例.
- 了解重症患者的特征对于管理严重流感感染至关重要.
研究的目的:
- 在加拿大,对患有2009年流感A(H1N1) 的危急病患者进行鉴定.
- 描述他们的治疗和结果,包括死亡率和资源利用.
主要方法:
- 对168名确诊或可能患有2009年流感A (H1N1) 的危急病患者进行前性观察性研究.
- 来自加拿大38个成人和儿科重症监护室 (ICU) 的数据.
- 主要结局:28天和90天死亡率;次要结局:机械呼吸和ICU停留时间.
主要成果:
- 该研究包括年轻人和儿童,其中女性和加拿大原住民比例很高.
- 患者呈现出快速危急疾病,严重的低氧化血和频繁的多系统器官衰竭.
- 观察到高机械通风率 (81.0%) 和长时间的重症监护室停留 (中位数为12天),以及频繁使用救援疗法.
结论:
- 从2009年流感A (H1N1) 引发的危急疾病迅速发展,影响了年轻人.
- 严重的低氧化,器官衰竭和长时间的机械通风是常见的,需要进行密集护理干预.
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