在对大肠杆菌的长期实验中,基因组的进化和适应
Jeffrey E Barrick1, Dong Su Yu, Sung Ho Yoon
1Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824, USA.
Nature
|October 20, 2009
概括
大肠杆菌的基因组进化显示了20,000代持续的有益突变,与中性进化预期相反. 后来,突变率升高导致了可变中性突变.
科学领域:
- 进化生物学 进化生物学
- 基因组学就是基因组学.
- 微生物进化 微生物进化
背景情况:
- 基因组进化率与生物体适应之间的联系尚未得到充分理解.
- 在实验室环境中的实验进化提供了一个强大的模型来研究这种关系.
研究的目的:
- 通过长期的实验进化来研究基因组进化和适应之间的关系.
- 在受控环境中精确跟踪基因组变化以及适应性转变.
主要方法:
- 从一个实验性大肠杆菌菌群体的基因组测序超过4万代.
- 在整个实验中分析突变积累和适应性变化.
主要成果:
- 基因组进化在最初的2万代人中保持了显著的稳定性,尽管适应速度有所减缓.
- 证据表明,在这一时期的大多数突变都是有益的,而不是中性的.
- 后来,该群体进化了突变率的增加,积累了许多中性突变.
结论:
- 基因组和适应性进化之间的相互作用是复杂的,并且可能与直觉相反.
- 有益替代显示时间均性,而中性替代随着时间的推移具有很高的变化.
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