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Updated: Jun 19, 2026

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
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Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities

Published on: October 2, 2018

叶绿素II (康普莱斯塔丁) 和叶绿素I的总合成

Joie Garfunkle1, F Scott Kimball, John D Trzupek

  • 1Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|October 21, 2009
PubMed
概括

通过使用新的宏循环化策略,首次实现了二烯II (1) 和二烯I (2) 的总合成. 这项研究引入了一种高效的拉洛克醇合成,用于构建复杂的循环.

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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...