性酸盐酶,血清酸盐和所有原因或心血管死亡率之间的关系
Marcello Tonelli1, Gary Curhan, Marc Pfeffer
1Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. mtonelli-admin@med.ualberta.ca
Circulation
|October 21, 2009
概括
较高的血清酸酸酶 (AlkP) 水平与没有功能衰竭的个体的死亡风险增加有关,包括心脏病发作幸存者和一般人群. 即使控制其他健康因素时,这种关联仍然存在.
科学领域:
- 生物化学 生物化学
- 临床医学 临床医学
- 流行病学 流行病学
背景情况:
- 血清性酸酶 (AlkP) 的升高是透析患者死亡的已知危险因素.
- 在没有功能衰竭的个体中,AlkP水平与不良结果之间的关联在很大程度上是未知的.
研究的目的:
- 研究血清酸酸酶 (AlkP) 水平与不良健康结果,特别是心血管事件和死亡率之间的关系.
- 为了确定这种关联是否存在于没有慢性病的人群中.
主要方法:
- 对胆固醇和复发事件 (CARE) 研究 (n=4115) 对心血管结果的分析.
- 用第三次全国健康和营养检查调查 (NHANES III) (n=14,716) 验证所有原因和心血管死亡率.
- 针对潜在的混因素进行统计调整,包括血清酸盐和肝酶.
主要成果:
- 在CARE参与者中观察到更高的AlkP三位体和增加的全因死亡率之间的分级独立关联 (P(趋势) =0.02).
- 与最低的三分之一相比,在最高的AlkP三分之一的人群中,死亡风险比率增加了43% (aHR=1.43).
- 在NHANES III队列中发现了类似的关联,较高的AlkP与所有原因和心血管死亡率的增加有关 (P ((趋势) =0.006和0.038,分别),无论病状况如何.
结论:
- 较高的血清酸酸酶 (AlkP) 水平独立地与不良结果相关,包括死亡率.
- 这种风险在心肌梗塞的幸存者和普通人群中很明显,即使在没有脏疾病的个体中也是如此.
- 死亡风险在具有高AlkP和血清酸盐水平同时存在的个体中特别高.
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