心血管疾病和部骨折的风险
Ulf Sennerby1, Håkan Melhus, Rolf Gedeborg
1Department of Surgical Sciences, Section of Orthopaedics, Uppsala University, SE-751 85 Uppsala, Sweden.
JAMA
|October 22, 2009
概括
心血管疾病 (CVD) 显著增加关节骨折的风险. 共同的遗传因素,而不仅仅是生活方式,有助于CVD和骨质疏松性骨折之间的这种联系.
科学领域:
- 老年学是指老年学的学科.
- 流行病学 流行病学
- 遗传学 是一个遗传学.
背景情况:
- 新出现的证据将心血管疾病 (CVD) 与骨质疏松性骨折联系起来.
- 对于这些常见的疾病,人们怀疑有共同的潜在病因.
研究的目的:
- 调查心血管疾病与随后的关节骨折风险之间的关联.
- 通过双胞胎研究设计,确定遗传和生活方式因素在这种关系中的作用.
主要方法:
- 从50岁开始对31,936名瑞典双胞胎 (出生于1914年至1944年) 进行了跟踪.
- 心血管疾病 (CVD) 和关节骨折数据从国家登记处 (1964-2005) 收集.
- 考克斯的比例危险回归模型分析了依赖时间的暴露.
主要成果:
- 心血管疾病的诊断与大大增加的关节骨折率有关 (例如,心力衰竭HR=4.40,中风HR=5.09).
- 即使是没有心血管疾病诊断的双胞胎也显示关节骨折风险较高,这表明他们有共同的遗传影响.
- 在伪暴露的双胞胎中,关节骨折的危险比为心力衰竭的3.74,中风的2.29.
结论:
- 心血管疾病是随后部骨折的重要危险因素.
- 在双胞胎中观察到的风险增加表明,一种遗传成分是心血管疾病与骨质疏松性骨折关联的基础.
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