长期疟疾预防的有效性和耐受性与梅花. 需要更好的剂量方案
H O Lobel1, K W Bernard, S L Williams
1Division of Parasitic Diseases, Centers for Disease Control, Atlanta, Ga 30333.
JAMA
|January 16, 1991
概括
与克洛洛奎因相比,梅弗洛奎因预防疟疾的有效性有所提高. 然而,每两周一次的治疗方案的血液水平较低,这表明每周一次剂量可能更好地预防Plasmodium falciparum感染.
科学领域:
- 热带医学是一种热带医学.
- 药理学 药理学是指药理学的学科.
- 传染病 传染病 传染病
背景情况:
- 疟疾仍然是一个重大的全球健康威胁,特别是菌菌.
- 素耐药性需要使用替代的预防策略.
- 梅花素是疟疾预防的潜在替代品.
研究的目的:
- 为了比较长期疟疾预防的美弗洛昆与洛昆的疗效和安全性.
- 为了评估不同剂量频率对美弗洛有效性的影响.
- 评估与美弗洛相关的不良反应预防.
主要方法:
- 一项涉及西非和平队志愿者的比较研究.
- 志愿者每隔两周接受甲floquine 或每周接受一次 chloroquine 酸盐.
- 记录了Plasmodium falciparum疟疾和不良事件的发生率.
主要成果:
- 梅花素在预防疟疾方面表现出比黄素更高的63%的有效性.
- 每月P.falciparum感染的发病率为每100名接受美弗洛治疗的志愿者中的1人,而接受洛治疗的志愿者中的每100人中有2.7人.
- 甲floquine的预防失败发生在每两周一次的治疗方案的第二周,与较低的血度有关.
结论:
- 对于前往克洛洛昆耐药疟疾地区的旅行者,应考虑每周服用梅花 (250毫克) 预防.
- 每两周一次的梅弗洛昆治疗方案可能是不理想的,因为血液水平下降.
- 梅弗洛奎因耐受性很好,没有发现严重的不良反应.
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