Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Hair Cells01:22

Hair Cells

Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
The Cochlea01:13

The Cochlea

The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
Auditory Pathway01:15

Auditory Pathway

Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking the...
Anatomy of the Ear01:16

Anatomy of the Ear

Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
Hearing01:31

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
Postsynaptic Potential (PSP)01:32

Postsynaptic Potential (PSP)

Postsynaptic potential (PSP) refers to a change in the electrical potential of a neuron when neurotransmitters released by presynaptic neurons bind to postsynaptic receptors. This potential can either be excitatory, leading to depolarization and ultimately action potential generation, or inhibitory, leading to hyperpolarization and suppression of the postsynaptic neuron.
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Dopaminergic modulation of low- and high-spontaneous rate type I auditory nerve fiber activity.

Journal of neurophysiology·2026
Same author

Functional Contributions of Quantal and Nonquantal Hair Cell Synaptic Transmission in the Vestibular Periphery.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Enhanced Sampling for Efficient Learning of Coarse-Grained Machine Learning Potentials.

Journal of chemical theory and computation·2025
Same author

Increased vulnerability to noise exposure of low spontaneous rate type 1C spiral ganglion neuron synapses with inner hair cells.

Hearing research·2025
Same author

Machine Learning Guided Video Analysis Identifies Sound-Evoked Pain Behaviors from Facial Grimace and Body Cues in Mice.

bioRxiv : the preprint server for biology·2025
Same author

Functional contributions of quantal and non-quantal hair cell synaptic transmission in the vestibular periphery.

bioRxiv : the preprint server for biology·2025

相关实验视频

Updated: Jun 19, 2026

Postsynaptic Recordings at Afferent Dendrites Contacting Cochlear Inner Hair Cells: Monitoring Multivesicular Release at a Ribbon Synapse
11:45

Postsynaptic Recordings at Afferent Dendrites Contacting Cochlear Inner Hair Cells: Monitoring Multivesicular Release at a Ribbon Synapse

Published on: February 10, 2011

第二种类型的耳 afferents 的 postsynaptic 功能.

Catherine Weisz1, Elisabeth Glowatzki, Paul Fuchs

  • 1The Department of Neuroscience, The Center for Hearing and Balance and the Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Nature
|October 23, 2009
PubMed
概括
此摘要是机器生成的。

已经证明,二类耳神经元,以前人们对它们的了解很少,是听觉附带神经元. 它们对强烈的声音和ATP做出反应,这表明与I型神经元相比,它们在听力中起着不同的作用.

更多相关视频

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea
09:54

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

Published on: May 10, 2019

Auditory Brainstem Response and Outer Hair Cell Whole-cell Patch Clamp Recording in Postnatal Rats
09:23

Auditory Brainstem Response and Outer Hair Cell Whole-cell Patch Clamp Recording in Postnatal Rats

Published on: May 24, 2018

相关实验视频

Last Updated: Jun 19, 2026

Postsynaptic Recordings at Afferent Dendrites Contacting Cochlear Inner Hair Cells: Monitoring Multivesicular Release at a Ribbon Synapse
11:45

Postsynaptic Recordings at Afferent Dendrites Contacting Cochlear Inner Hair Cells: Monitoring Multivesicular Release at a Ribbon Synapse

Published on: February 10, 2011

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea
09:54

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

Published on: May 10, 2019

Auditory Brainstem Response and Outer Hair Cell Whole-cell Patch Clamp Recording in Postnatal Rats
09:23

Auditory Brainstem Response and Outer Hair Cell Whole-cell Patch Clamp Recording in Postnatal Rats

Published on: May 24, 2018

科学领域:

  • 神经科学是一个神经科学.
  • 审计系统研究 审计系统研究
  • 细胞生物学 细胞生物学

背景情况:

  • 哺乳动物的耳有两种感觉神经元类型:I型 (90-95%) 和II型.
  • I型神经元激活内部毛细胞进行声学分析.
  • 二类神经元,罕见且研究不足,内化外部毛细胞和支持细胞.

研究的目的:

  • 研究II型耳神经元的功能和突触输入.
  • 确定II型神经元对声学刺激和ATP的反应.
  • 阐明II型神经元在听觉信号传递中的作用.

主要方法:

  • 从外发细胞附近的II型神经元纤维的电生理学记录.
  • 外源ATP的应用,以评估神经元脱极化.
  • 在II型神经元中分析突触输入和动能传导.

主要成果:

  • 第二类神经元接收激发性谷氨基酶突触输入.
  • 谷氨酸刺激需要强烈的声学刺激.
  • 第二类神经元由ATP脱极化,直接或通过唤起的谷氨酸输入.
  • 二型神经元的突触驱动力比I型神经元的突触驱动力小.

结论:

  • 第二类神经元作为耳附带神经元起作用.
  • 第二类神经元是由ATP调节的.
  • 由于其独特的响应特性,II型神经元与I型神经元相比具有独特的听觉信号传递作用.