人类测量,体脂肪和静脉血栓栓塞:丹麦的后续研究
Marianne Tang Severinsen1, Søren Risom Kristensen, Søren Paaske Johnsen
1Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg Hospital, Sdr. Skovvej 15, DK-9000 Aalborg, Denmark. m.severinsen@rn.dk
Circulation
|October 28, 2009
概括
所有的肥胖测量,包括体重指数和腰或部周长,预测静脉血栓栓塞 (VTE) 风险. 这项研究强调了不同的体脂测量与男性和女性的VTE有关.
科学领域:
- 心血管健康 心血管健康
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 体重指数 (BMI) 表示的肥胖与静脉血栓栓塞 (VTE) 有关.
- 体重指数 (BMI) 虽然是衡量多余体重的指标,但并不考虑身体脂肪的分布.
- 各种人体测量方法与VTE风险之间的关系需要进一步研究.
研究的目的:
- 评估人体测量变量与VTE之间的关联.
- 为了确定除了整体肥胖之外,身体脂肪分布是否会影响静脉瘤风险.
主要方法:
- 一项针对57,054名年龄在50-64岁的人进行的前性研究 (饮食,癌症和健康研究).
- 使用丹麦国家患者登记册和医疗记录进行了为期10年的随访,以确定VTE事件.
- 考克斯的比例危险模型用于分析人体测量 (体重,BMI,腰/部周长,总体脂肪) 和VTE之间的关联,调整为混因素.
主要成果:
- 验证了641个事件VTE事件.
- 在两性中观察到VTE和所有人体测量之间的单调剂量-反应关系.
- 女人与静脉瘤相关的部周长;在相互调整后,男性与静脉瘤相关的腰围.
结论:
- 所有的肥胖测量都是VTE风险的显著预测指标.
- 体重,BMI,腰围,部周长和总体脂肪与静脉瘤有积极的关联.
- 特定的身体脂肪分布模式 (腰围与部周长) 显示了与静脉瘤风险的性别相关联.
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