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进入代谢综合征的轨迹:弗雷明汉姆心脏研究

Oscar H Franco¹, Joseph M Massaro, Jacky Civil

¹Unilever Corporate Research, Sharnbrook, UK. O.H.Franco@warwick.ac.uk

|November 4, 2009

概括

患有特定风险因素组合的代谢综合征 (MetS) 的人面临更高的心血管疾病和死亡风险. 早期识别和治疗这些高风险群体对于更好的结果至关重要.

科学领域:

心脏病学心脏病学
内分泌学在内分泌学.
公共卫生公共卫生

背景情况:

代谢综合征 (MetS) 是一个日益严重的公共卫生问题.
了解MetS进展及其组成部分对于预测不良健康结果至关重要.

研究的目的:

评估MetS及其组成部分的进展情况.
为了确定MetS的个别轨迹.
确定这些轨迹如何预测心血管疾病和死亡率.

主要方法:

分析了来自弗雷明汉姆后代研究 (1987-1995) 的3078名参与者.
根据成人治疗小组III标准定义的MetS.
后勤回归用于评估MetS开发的组件预测能力.
根据MetS组件组合计算心血管事件和死亡率的危险比率.

主要成果:

在10年内,MetS患病率翻了一番;高血糖症和中心肥胖症增加最多.
在MetS诊断时,高血压是最常见的 (77.3%).
中部肥胖症对发展METS的风险最高 (OR,4.75).
中心肥胖,高血压和高血糖症的组合显著增加了心血管事件风险 (HR, 2.36) 和死亡风险 (HR, 3.09).

结论:

特定的MetS轨迹和因素组合显著增加心血管疾病和死亡风险.
针对这些高风险人群进行有针对性的鉴定和早期干预至关重要.
需要加大努力来管理MetS进展并减轻相关风险.

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