检测心肌损伤在患有沙尔科毒素症的患者
Manesh R Patel1, Peter J Cawley, John F Heitner
1Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Durham, NC 27710, USA.
Circulation
|November 4, 2009
概括
延迟增强心血管磁共振 (DE-CMR) 对于检测心脏肉类瘤比标准方法更为敏感. 这种成像技术可以识别心肌损伤,与增加不良事件和心脏死亡风险相关.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 肺部病理学 肺部病理学
背景情况:
- 突发性死亡是沙尔科毒症患者死亡的主要原因,通常是由于未被识别的心脏参与.
- 延迟增强心血管磁共振 (DE-CMR) 可以检测到微妙的心肌损伤.
研究的目的:
- 为了比较DE-CMR的疗效与标准的临床评估在确定心脏参与在肉类发病患者.
- 评估DE-CMR发现与心血管不良事件之间的关联.
主要方法:
- 八十一名经过活检证明的患有沙丘症的患者进行了并行,掩盖的DE-CMR和标准临床评估 (心电图加上另一项心脏研究) 的比较.
- 随访患者主要不良事件,包括死亡,除器冲击或起器要求.
主要成果:
- 在26%的患者中,DE-CMR发现了心脏干扰,比标准标准 (P=0.005) 的两倍多 (12%).
- 在DE-CMR检测到心肌损伤的患者中,不良事件的发生率高出9倍,心脏死亡率高出11.5倍.
- 病理学证实了DE-CMR在识别心脏沙丘病症时的更高灵敏度.
结论:
- 德-CMR显著比目前的共识标准更敏感,用于检测心脏参与沙尔科毒症.
- 通过DE-CMR识别的心肌损伤与未来不良事件的风险增加有关,包括心脏病死亡,这需要在更大的队列中进一步调查.
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