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Updated: Jun 19, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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蛋白质 - 连接体相互作用中的形状约束的热力学和结构效应. 与连接体预组织相关的热悖论

John E DeLorbe1, John H Clements, Martin G Teresk

  • 1Department of Chemistry and Biochemistry, The Institute of Cellular and Molecular Biology, University of Texas, Austin, Texas 78712, USA.

Journal of the American Chemical Society
|November 6, 2009
PubMed
概括

与常见假设相反,Grb2 SH2域相互作用中的配体预组织并没有改善结合. 预先组织的连接体中有利的结合率导致了 affinity 的增加,突出了预测蛋白质-连接体相互作用的复杂性.

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