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HMGB蛋白质作为核酸介导的先天免疫反应的通用哨兵

Hideyuki Yanai1, Tatsuma Ban, ZhiChao Wang

  • 1Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

Nature
|November 6, 2009
PubMed
概括

高流动性组盒 (HMGB) 蛋白质充当通用哨兵,结合所有免疫性核酸. 它们的缺失会损害先天的免疫反应,揭示了核酸感知对免疫至关重要的层次结构.

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