CD8 ((+) T淋巴细胞向病毒感染组织的动员需要CD4 ((+) T细胞的帮助
Yusuke Nakanishi1, Bao Lu, Craig Gerard
1Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Nature
|November 10, 2009
概括
CD4 ((+) T辅助细胞对于效应细胞毒性CD8 ((+) T淋巴细胞 (CTL) 细胞迁移到受感染的组织至关重要. 这些CD4(+) T细胞通过IFN-和化学酶间接引导CTL,使病原体清除.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- T细胞免疫学T细胞免疫学
背景情况:
- CD4 ((+) T辅助细胞对于启动和维持CD8 ((+) T淋巴细胞 (CTL) 反应至关重要.
- CD4 ((+) T细胞在CTL反应的效应器阶段的帮助作用在很大程度上仍未被探索.
研究的目的:
- 调查CD4 (((+) T辅助细胞在组织层面控制效应器CTL反应中的功能.
- 阐明CD4(+) T细胞在感染期间影响CTL活动的机制.
主要方法:
- 涉及T细胞激活和迁移试验的体内研究.
- 对感染组织中细胞因子 (IFN-) 和化学因子表达的分析.
- 在有或没有CD4 ((+) T细胞的帮助下,研究效能体CTL的迁移能力.
主要成果:
- 效应器CTLs需要CD4 ((+) T细胞的协助,以便有效地进入受感染的外围组织.
- CD4(+) T辅助细胞通过 IFN-的分泌间接调解这种作用.
- IFN-gamma诱导局部化学激素的产生,这反过来又引导CTL迁移到感染部位.
结论:
- CD4 ((+) T辅助细胞在编排效应器CTL功能方面发挥着至关重要的,以前未被认可的作用.
- CD4 ((+) T细胞衍生信号是调动效应体CTL到外围感染部位的必不可少的.
- 这种CD4 ((+) T细胞介导的动员对于有效消除受感染细胞至关重要.
相关概念视频
T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
Immune Response Against Viral Pathogens
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Cytotoxic T Cells-mediated Immune Response
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Cell-mediated Immune Responses
Overview


