9p21的一个常见变体与突然和心律失常的心脏死亡有关
Christopher Newton-Cheh1, Nancy R Cook, Martin VanDenburgh
1MPH, Center for Arrhythmia Prevention, Division of Preventive Medicine, Cardiovascular Division, Brigham and Women's Hospital, 900 Commonwealth Ave E, Boston, MA 02115-1204, USA.
Circulation
|November 11, 2009
概括
染色体9p21中的一个常见的遗传变异 (rs10757274) 与欧洲祖先个体突然心脏死亡 (SCD) 的风险增加有关. 这一发现可能有助于更好地了解致命的心血管疾病.
科学领域:
- 心血管遗传学 心血管遗传学
- 遗传流行病学遗传流行病学
- 突发心脏病死亡研究研究
背景情况:
- 家庭史表明突然心脏死亡 (SCD) 的遗传基础,但常见的遗传因素仍然难以捉摸.
- 之前与心肌梗塞相关的9p21染色体的一个常见变异被假定会影响SCD风险.
研究的目的:
- 调查9p21染色体的一个常见遗传变异与心脏突然死亡 (SCD) 风险之间的关联.
主要方法:
- 来自6项队列研究的欧洲血统个体的前性,嵌套,病例控制分析.
- 在492例SCD病例和1460例对照中进行rs10757274的基因型鉴定,根据关键的人口和临床因素进行匹配.
- 固定效应的元分析使用条件后勤回归来评估附加模型下的关联.
主要成果:
- 在rs10757274的G等位基因的每个额外副本都与SCD的几率比率增加显著相关 (OR,1.21;P=0.01).
- 在控制心血管和生活方式风险因素 (OR,1.29;P=0.003) 后,这种关联得到加强.
- 结果在敏感性分析中保持一致,包括那些考虑过渡性心血管疾病的结果.
结论:
- 之前与冠状动脉疾病事件相关的单核酸多态 (SNP) 也与欧洲祖先人群中SCD风险增加有关.
- 对这种遗传关联背后的机制进行进一步的研究可以提高对致命心血管疾病的理解.
更多相关视频
相关概念视频
Mechanism of Cardiac Arrhythmias
2.7K
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
2.7K
Disturbances in Heart Rhythm
5.3K
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
5.3K
Coronary Artery Disease III: Clinical Manifestations
620
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
620
Dysrhythmias II: Classification of Tachyarrhythmias
735
Tachyarrhythmias are a type of dysrhythmia where the heart rate exceeds 100 beats per minute. Here are some common types of tachyarrhythmias:Sinus TachycardiaSinus tachycardia originates from increased impulses from the sinus node, leading to an elevated heart rate. It is often triggered by stress, fever, or exercise.Patients may experience palpitations, a sensation of a racing heart, dizziness, and chest discomfort.Causes and Risk Factors: Common causes include physical exertion, emotional...
735
Cardiomyopathy III: Hypertrophic Cardiomyopathy
805
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
805
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
1.2K
Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
1.2K


