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Updated: Apr 2, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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直接抑制NOTCH转录因子复合物的直接抑制

Raymond E Moellering1, Melanie Cornejo, Tina N Davis

  • 1Department of Chemistry & Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

Nature
|November 13, 2009
PubMed
概括

研究人员开发了一种新型的抑制剂SAHM1,可以有效地阻止NOTCH交换激活复合体. 这种有针对性的方法对治疗NOTCH驱动的癌症,如T细胞急性淋巴细胞白血病 (T-ALL) 有希望.

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