最终:Smads的最后几分钟
1State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Tsinghua University, Beijing 100084, China. ygchen@tsinghua.edu.cn
Cell
|November 17, 2009
概括
转化增长因子-β (TGF-β) 信号涉及Smad蛋白酸化. 这种链接酸化对于Smad激活和随后的降解都至关重要,揭示了双重调节作用.
科学领域:
- 分子生物学分子生物学
- 细胞信号传递 细胞信号传递
- 生物化学 生物化学
背景情况:
- 转化生长因子-β (TGF-β) 信号通路在细胞过程中至关重要.
- 受体调节的Smad (R-Smad) 蛋白质是TGF-β的关键介质.
- 酸化R-Smads是一种已知的调节机制.
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