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Updated: Jun 18, 2026

Structure of HIV-1 Capsid Assemblies by Cryo-electron Microscopy and Iterative Helical Real-space Reconstruction
12:38

Structure of HIV-1 Capsid Assemblies by Cryo-electron Microscopy and Iterative Helical Real-space Reconstruction

Published on: August 9, 2011

-EM和NMR之间的结构融合揭示了对HIV-1囊功能至关重要的子单位间相互作用

In-Ja L Byeon1, Xin Meng, Jinwon Jung

  • 1Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.

Cell
|November 17, 2009
PubMed
概括

这项研究揭示了HIV-1囊蛋白 (CA) 结构和接口如何使病毒组装和拆卸成为可能. 了解这些囊体动态是开发新抗病毒策略的关键.

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相关概念视频

Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...