洛瓦斯塔丁在降低低密度脂蛋白胆固醇水平的有效性在高脂或低脂饮食中
M M Cobb1, H S Teitelbaum, J L Breslow
1Laboratory of Biochemical Genetics, Rockefeller University, New York, NY.
JAMA
|February 27, 1991
概括
洛瓦斯塔丁有效降低胆固醇和LDL胆固醇,与或没有高脂肪饮食. 建议与洛瓦斯塔丁一起进行低脂肪饮食,以获得最佳的胆固醇降低.
科学领域:
- 心脏病学 心脏病学
- 营养科学 营养科学
- 药理学 药理学 是一个学科.
背景情况:
- 高胆固醇血症带来了显著的心血管风险.
- 饮食干预和他类药物是主要的管理策略.
- 了解饮食和他类药物的疗效之间的相互作用至关重要.
研究的目的:
- 在高胆固醇和低脂肪饮食的高胆固醇患者中,比较洛瓦斯塔丁与安慰剂的有效性.
- 评估潜在的饮食药物相互作用.
- 确定洛瓦斯塔丁和饮食对脂蛋白水平的影响,并实现临床指南.
主要方法:
- 在代谢病房条件下进行了一项随机对照试验.
- 患有高胆固醇血症的受试者在3周的饮食期内接受了洛瓦斯塔丁 (40毫克/天) 或安慰剂.
- 脂蛋白水平 (总胆固醇,LDL-C,HDL-C) 在每个饮食期的最后一周测量.
主要成果:
- 与安慰剂相比,洛瓦斯坦丁显著降低了总胆固醇 (23%) 和LDL胆固醇 (30%),无论饮食如何.
- 没有观察到显著的饮食药物相互作用.
- 低脂肪饮食与洛瓦斯塔丁相结合,使更多的受试者 (80%) 比高脂肪饮食 (不到50%) 能够达到胆固醇指南.
- 高密度脂蛋白胆固醇在两种饮食方案中增加了7-8%.
结论:
- 洛瓦斯塔丁在降低LDL胆固醇方面表现出一致的有效性,无论饮食中的脂肪含量如何.
- 虽然洛瓦斯塔丁是有效的,但低脂肪饮食对于达到目标的LDL胆固醇水平至关重要.
- 将洛瓦斯塔丁与低脂肪饮食相结合是管理高胆固醇血症的最有效策略.
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