神经元亚型规范在一个谱系内通过对立的时间料前传循环.
Magnus Baumgardt1, Daniel Karlsson, Javier Terriente
1Department of Clinical and Experimental Medicine, Linkoping University, Linkoping SE-581 85, Sweden.
Cell
|December 1, 2009
概括
神经干细胞通过时间基因级联产生多种细胞类型. 这项研究揭示了子基因如何使用Drosophila的相反的前循环将宽的时间窗子细分为特定的细胞命运.
科学领域:
- 发育生物学是发展生物学.
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
背景情况:
- 神经前代会随着时间的推移产生多样化的细胞类型,但控制这些时间过渡的机制仍然不清楚.
- 在Drosophila中枢神经系统中的"时间基因级联"涉及转录因子,改变了祖先能力.
- 神经干细胞谱系中的时间窗口有多广泛地分裂以产生独特的细胞类型,目前尚不清楚.
研究的目的:
- 研究神经祖先系中广泛的时窗的细分机制.
- 阐明Drosophila中枢神经系统中更广泛的时间窗口内如何产生特定的细胞命运.
- 了解子基因在时间进展和细胞命运多样化中的作用.
主要方法:
- 在多索菲拉中枢神经系统 (CNS) 中对可识别的神经祖先系的分析.
- 研究子基因的功能及其下游目标.
- 识别和描述控制时间基因表达的前调节循环.
主要成果:
- 发现一个宽的子时窗被两个不同的前循环细分,两者都是由子启动的.
- 第一个前循环指定了一个独特的细胞命运.
- 第二个前循环抑制了第一个循环,使得产生替代细胞命运.
结论:
- 神经祖先的时间进展是由涉及"时间"和"次时间"基因的基因级联调节的.
- 由子触发的对立的前循环,细分广泛的时间窗口以产生细胞类型的多样性.
- 这种调节机制可以在各种干细胞系中保存,以产生细胞多样性.
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