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Updated: Jun 18, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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核酸的循环和骨干修改改善了g-四重复结合选择性

Sabrina Lusvarghi1, Connor T Murphy, Subhadeep Roy

  • 1Departments of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA.

Journal of the American Chemical Society
|December 2, 2009
PubMed
概括

研究人员修改了富含关氨酸的核酸 (PNA) 寡合体,以提高G-四重复形成对双重复的选择性. 脊柱修改改善了PNA与向DNA和RNA的结合,促进了基因调节和抗癌剂的开发.

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