运动可以防止循环白细胞和血管壁中的细胞衰老
Christian Werner1, Tobias Fürster, Thomas Widmann
1Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, 66421 Homburg/Saar, Germany.
Circulation
|December 2, 2009
概括
身体炼通过上调端粒稳定蛋白质并减少小鼠和人类的亡来增强血管健康. 这促进了内皮的抗压能力,并可能减缓衰老.
科学领域:
- 心血管生物学 心血管生物学
- 分子生物学分子生物学
- 老年学是一门学科.
背景情况:
- 运动对血管的益处的分子基础仍然不清楚.
- 端粒缩短与衰老和细胞衰老有关.
- 了解运动对端粒生物学的影响对于衰老研究至关重要.
研究的目的:
- 研究运动如何影响小鼠血管端粒生物学和内皮细胞亡.
- 检查耐力训练对人类运动员端粒生物学的影响.
- 为了阐明运动诱导的血管保护背后的分子机制.
主要方法:
- 小鼠进行了3周的自愿跑步;对大动脉和血液中的关键分子标志物进行了分析.
- 转基因小鼠模型探索了 eNOS 和 TERT 的协同效应.
- 人类运动员的白细胞端粒生物学与未经训练的个人进行了比较.
主要成果:
- 运动增加了小鼠血管和血液中的端粒酶活性和端粒结合蛋白 (TRF2,Ku70).
- 运动减少了细胞亡调节剂 (CHK2,p16,p53) 并防止诱导的细胞亡.
- 耐力运动员表现出更高的端粒酶活性,稳定端粒和更少的细胞循环抑制剂.
结论:
- 身体活动对小鼠和人类的端粒稳定蛋白进行调节.
- 运动可以防止压力诱导的血管亡.
- 运动在维持血管健康和潜在地缓解衰老过程方面发挥着重要作用.
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