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Updated: Jun 18, 2026

Identification of Kinase-substrate Pairs Using High Throughput Screening
11:13

Identification of Kinase-substrate Pairs Using High Throughput Screening

Published on: August 29, 2015

高通量选以确定稳定p38alpha中非活性激酶构造的抑制剂

Jeffrey R Simard1, Christian Grütter, Vijaykumar Pawar

  • 1Chemical Genomics Centre of the Max Planck Society, Otto-Hahn-Strasse 15, D-44227 Dortmund, Germany.

Journal of the American Chemical Society
|December 3, 2009
PubMed
概括

这项研究选了非活性的人类p38alpha MAP激酶,以找到新的小分子激酶抑制剂. 该试验确定了稳定DFG-out形状的化合物,这是传统方法错过的.

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