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相关概念视频

Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...
Cellular Differentiation00:57

Cellular Differentiation

How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Lines01:16

Cell Lines

A cell line is a population of cells grown in vitro that can be subcultured over several generations. Normal cells cease to divide after a certain number of cell divisions, a process known as replicative senescence. This number, called the Hayflick limit, was conceptualized by Leonard Hayflick in 1961 when he observed that fetal cells grown in culture could only divide 40-60 times. This limit is due to the shortening of the telomeres during each round of cell division, preventing cell division...

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相关实验视频

Updated: Jun 18, 2026

A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice
07:48

A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice

Published on: December 18, 2015

强迫细胞改变血统.

Thomas Graf1, Tariq Enver

  • 1Center for Genomic Regulation and ICREA, 08003 Barcelona, Spain. thomas.graf@crg.es

Nature
|December 4, 2009
PubMed
概括

诱导多能性 (iPS重编程) 恢复了对直接细胞系重编程的兴趣. 这种技术为研究细胞命运提供了强大的方法,并有可能用于治疗应用.

科学领域:

  • 细胞生物学 细胞生物学
  • 发育生物学是发展生物学.
  • 分子生物学分子生物学

背景情况:

  • 诱导多能性 (iPS重编程) 能够产生干细胞.
  • 转录因子已被证明可以直接在血统之间转换专门的细胞.

研究的目的:

  • 探索直接血统重编程的含义.
  • 突出其在理解细胞命运决定方面的有用性.
  • 讨论其治疗策略的潜力.

主要方法:

  • 关于转录因子介导的细胞转化早期研究的综述.
  • 诱导多能性 (iPS重编程) 技术的分析.
  • 在分化过程中探索细胞命运选择机制.

主要成果:

  • 直接血统重编程是细胞命运研究的一个可行的方法.
  • 这种方法提供了与遗传突变研究可比的见解.
  • 获得的理解可以为治疗细胞操纵提供信息.

结论:

  • 血统重编程是生物研究中的一个有价值的工具.

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Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans
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Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans

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A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice
07:48

A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice

Published on: December 18, 2015

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11:46

Direct Lineage Reprogramming of Adult Mouse Fibroblast to Erythroid Progenitors

Published on: December 14, 2018

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans
07:53

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans

Published on: January 1, 2018

  • 它为开发新型治疗干预提供了一个框架.
  • 对细胞操纵的进一步研究具有显著的前景.