Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cationic Chain-Growth Polymerization: Mechanism00:57

Cationic Chain-Growth Polymerization: Mechanism

The cationic polymerization mechanism consists of three steps: initiation, propagation, and termination. In the initiation step of the polymerization process, the π bond of a monomer gets protonated by the Lewis acid catalyst, which is formed from boron trifluoride and water. The protonation of the π bond generates a carbocation stabilized by the electron‐donating group. In the propagation step, the π bond of the second monomer acts as a nucleophile and attacks the generated carbocation,...
Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Combined Islet and Kidney Xenotransplantation for Diabetic Nephropathy: Investigation of Pre-Vascularized Composite Grafts versus Sequential Islet-After-Kidney Transplantation in a Pig-to-Nonhuman Primate Model of Xenotransplantation.

Xenotransplantation·2026
Same author

A metabolic boost to mRNA vaccines.

Nature materials·2026
Same author

N-acetylcysteine modulates neutrophil-driven immune and metabolic pathways in steatotic liver ischemia-reperfusion injury.

Frontiers in immunology·2026
Same author

Photocontrolled immunotherapy: a BODIPY-caged MSA-2 for spatiotemporal activation of STING with visible light.

New journal of chemistry = Nouveau journal de chimie·2026
Same author

A molecularly defined polymeric platform for environmentally responsive activation of STING to enhance cancer immunotherapy.

Biomaterials·2026
Same author

Chimerism and a framework for clinical practice: A report from the Cellular Therapies Section Coordinating Committee (CTSCC) of Association for Advancement of Blood and Biotherapies (AABB).

Transfusion·2026

相关实验视频

Updated: Jun 18, 2026

Grafting Multiwalled Carbon Nanotubes with Polystyrene to Enable Self-Assembly and Anisotropic Patchiness
11:09

Grafting Multiwalled Carbon Nanotubes with Polystyrene to Enable Self-Assembly and Anisotropic Patchiness

Published on: April 1, 2018

非共价细胞表面工程用阴离子接种共聚物.

John T Wilson1, Venkata R Krishnamurthy, Wanxing Cui

  • 1Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 101 Woodruff Circle, Suite 5105 WMRB, Atlanta, Georgia 30322, USA.

Journal of the American Chemical Society
|December 8, 2009
PubMed
概括

研究人员开发了一种新方法,使用聚-氨酸-移植-聚乙烯甘醇 (PLL-g-PEG) 共聚合物来设计细胞表面. 这种技术允许安全有效的细胞表面修饰,使新的生物医学应用成为可能.

科学领域:

  • 生物材料科学 生物材料科学
  • 聚合物化学 聚合物化学
  • 细胞表面工程 细胞表面工程

背景情况:

  • 细胞表面工程对于修改细胞特性至关重要.
  • 现有的方法面临细胞毒性和特异性的挑战.

研究的目的:

  • 开发一种新的细胞表面再工程策略,使用功能化聚-氨酸-移植-聚乙烯基醇 (PLL-g-PEG) 共聚合物.
  • 为了证明这种方法对细胞表面修饰的安全性和有效性.

主要方法:

  • 合成和表征PLL-g-PEG共聚合物,其移植密度和PEG链长度各不相同.
  • 研究了PLL-g-PEG修饰细胞的细胞毒性和细胞活力.
  • 利用功能化的PLL-g-PEG共聚合物作为载体,将特定部分 (生物素,化物,亚化物) 引入细胞表面.

主要成果:

  • PLL-g-PEG共聚合物被吸附到细胞表面,而不会影响细胞活力.
  • 细胞毒性取决于电荷密度和PEG移植.
  • 功能化的共聚合物成功地引入了生物素,化物和亚化物部分,用于选择性探头捕获.

结论:

  • 定制的PLL-g-PEG共聚合物为细胞表面工程提供了一个安全和多功能平台.

更多相关视频

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion
06:15

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Published on: August 15, 2016

Preparation of Light-responsive Membranes by a Combined Surface Grafting and Postmodification Process
12:00

Preparation of Light-responsive Membranes by a Combined Surface Grafting and Postmodification Process

Published on: March 21, 2014

相关实验视频

Last Updated: Jun 18, 2026

Grafting Multiwalled Carbon Nanotubes with Polystyrene to Enable Self-Assembly and Anisotropic Patchiness
11:09

Grafting Multiwalled Carbon Nanotubes with Polystyrene to Enable Self-Assembly and Anisotropic Patchiness

Published on: April 1, 2018

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion
06:15

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Published on: August 15, 2016

Preparation of Light-responsive Membranes by a Combined Surface Grafting and Postmodification Process
12:00

Preparation of Light-responsive Membranes by a Combined Surface Grafting and Postmodification Process

Published on: March 21, 2014

  • 这一策略可以创建独特的细胞表面图案和组合修饰.
  • 这种方法具有生物医学和生物技术应用的巨大潜力.