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Updated: Jun 18, 2026

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
07:10

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Published on: September 14, 2014

在HIV-1 gp120上CD4附着部位的免疫逃避的结构基础

Lei Chen1, Young Do Kwon, Tongqing Zhou

  • 1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Science (New York, N.Y.)
|December 8, 2009
PubMed
概括

大多数针对HIV-1的CD4结合部位 (CD4BS) 的抗体都无法中和病毒. 结构分析显示,微妙的识别差异导致弱中和抗体与HIV-1 gp120结合在与病毒尖峰不相容的形状中,从而产生抗性.

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