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Updated: Jun 3, 2026

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants
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Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

大型,罕见的染色体缺失与严重的早期肥胖症相关

Elena G Bochukova1, Ni Huang, Julia Keogh

  • 1University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

Nature
|December 8, 2009
PubMed
概括

副本数量的变化,特别是大量的删除,与严重肥胖有显著的联系. 这些遗传变化,特别是染色体16p11.2的变化,与患者的过和胰岛素抵抗有关.

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A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations08:22

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