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Published on: October 16, 2010
豆类食物摄入量和乳腺癌存活率
Xiao Ou Shu1, Ying Zheng, Hui Cai
1Department of Medicine, Vanderbilt Epidemiology Center, 2525 West End Ave, Ste 600, Nashville, TN 37203-1738, USA. xiao-ou.shu@vanderbilt.edu
JAMA
|December 10, 2009
概括
乳腺癌诊断后食用大豆食品与较低的死亡率和复发率有关. 这一发现适用于各种乳腺癌类型和他莫西芬使用,为幸存者提供潜在的饮食益处.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 豆类食品含有异黄,强大的植物雌激素具有潜在的乳腺癌风险降低特性.
- 人们对大豆的雌激素作用和与乳腺癌治疗方法 (如坦莫西芬) 的相互作用存在担忧.
研究的目的:
- 研究乳腺癌幸存者的诊断后大豆食物摄入量和死亡率之间的关联.
- 评估大豆食品消费对乳腺癌复发率的影响.
主要方法:
- 一项对5042名中国女性乳腺癌幸存者的队列研究 (上海乳腺癌生存研究).
- 在诊断后收集有关饮食,生活方式和临床因素的数据,通过生命统计数据链接进行后续跟踪.
- 考克斯回归分析用于评估关联,调整混因素并将大豆摄入量作为时间依赖的变量.
主要成果:
- 较高的大豆食物摄入量 (大豆蛋白或异黄) 与总死亡率和癌症复发相反相关.
- 与最低四分位数相比,大豆蛋白摄入量最高四分位数的死亡风险降低了29%,复发风险降低了32%.
- 这些保护性关联在雌激素受体阳性和阴性乳腺癌以及塔莫西芬使用者和非使用者中都被观察到.
结论:
- 大豆食品消费与乳腺癌患者的死亡率降低和复发风险显著相关.
- 饮食大豆可能对乳腺癌幸存者有益,无论更年期状态或特定的治疗方案.
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