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相关概念视频

Structure of Cadherins01:25

Structure of Cadherins

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The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins”   is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This...
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Mechanism of Conjugation01:19

Mechanism of Conjugation

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Bacterial conjugation is a mechanism of horizontal gene transfer that enables the exchange of genetic material between bacterial cells through direct contact. This process is facilitated by a donor cell carrying a conjugative plasmid, which encodes genes necessary for pilus formation, DNA replication, and transfer. The conjugative plasmid plays a central role in initiating and executing the transfer of genetic material.The tra region of the conjugative plasmid encodes proteins responsible for...
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相关实验视频

Updated: May 1, 2026

Prescribed 3-D Direct Writing of Suspended Micron/Sub-micron Scale Fiber Structures via a Robotic Dispensing System
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Prescribed 3-D Direct Writing of Suspended Micron/Sub-micron Scale Fiber Structures via a Robotic Dispensing System

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一种基于结构的机制,用于通过多子单元连接复合体DSL1捕获囊泡.

Yi Ren1, Calvin K Yip, Arati Tripathi

  • 1Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

Cell
|December 17, 2009
PubMed
概括

最简单的绑定机器DSL1复合体捕获囊泡进行运输. 它的结构揭示了它如何结合SNARE蛋白来协调囊泡融合和流通.

科学领域:

  • 细胞生物学 细胞生物学
  • 分子和结构生物学分子和结构生物学.

背景情况:

  • 囊泡贩运依赖于膜融合,由SNARE蛋白驱动.
  • 连接复合体 (MTC) 介导了初始囊泡-位器官的附着.
  • Dsl1复合体是最简单的MTC,对于逆行COPI囊泡从戈尔吉到ER的运输至关重要.

研究的目的:

  • 为了确定DSL1复合体的结构.
  • 了解MTC功能在囊泡结合和融合中的结构基础.

主要方法:

  • 进行X射线晶体学以确定DSL1复杂结构.

主要成果:

  • Dsl1复合体具有塔状结构,底部有SNARE结合点,尖端有一个囊泡捕获拉索.
  • 该复合体将单个SNARE和组装的SNARE复合体结合在一起.
  • Dsl1加速了SNARE复杂组件的组装.

结论:

  • Dsl1复合体的结构有助于囊泡捕获,SNARE结合,以及潜在的SNARE复合体组装.
  • 即使是简单的MTC也可以协调囊泡贩运的多个步骤,包括捕获,脱涂和融合.

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