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缺少E2f的视网膜原体的分裂和亡

Danian Chen1, Marek Pacal, Pamela Wenzel

  • 1Toronto Western Research Institute, University Health Network, Department of Ophthalmology, and Laboratory Medicine and Pathobiology, University of Toronto, Ontario M5T 2S8, Canada.

Nature
|December 18, 2009
PubMed
概括

激活E2F转录因子对正常细胞分裂并不重要,但起到关键的促生存作用. 这些因素的丧失会通过一种新的E2F-Sirt1-p53生存途径导致亡的增加.

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