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Updated: May 2, 2026

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
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Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes

Published on: November 1, 2012

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DNA-PKcs的晶体结构揭示了一个由HEAT重复组成的大型开放环摇篮

Bancinyane L Sibanda1, Dimitri Y Chirgadze, Tom L Blundell

  • 1Department of Biochemistry, University of Cambridge, Old Addenbrooke's site, 80 Tennis Court Road, Cambridge CB2 1GA, UK. lynn@cryst.bioc.cam.ac.uk

Nature
|December 22, 2009
PubMed
概括

确定了人类DNA依赖蛋白激酶催化子单元 (DNA-PKcs) 的晶体结构,揭示了它在DNA双链断裂修复中的作用. 这一发现提供了对基因组稳定性和癌症预防机制的见解.

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