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杜基因酶USP9X稳定了MCL1并促进了瘤细胞的存活

Martin Schwickart1, Xiaodong Huang, Jennie R Lill

  • 1Department of Physiological Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.

Nature
|December 22, 2009
PubMed
概括

杜比基因酶USP9X稳定了MCL1,这是癌细胞生存的关键蛋白质. 抑制USP9X可能为治疗某些癌症,如淋巴瘤和多发性骨髓瘤提供新的治疗策略.

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