脂肪组织相关的c-Kit ((+) Sca-1 ((+) 淋巴细胞产生的T(H) 2细胞因子
Kazuyo Moro1, Taketo Yamada, Masanobu Tanabe
1Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.
Nature
|December 22, 2009
概括
研究人员在脂肪相关淋巴细胞群 (FALC) 中发现了一种新的先天性免疫细胞类型. 这些天然辅助细胞支持B细胞抗体的产生,并有助于驱逐虫感染.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 具有天生的免疫力.
背景情况:
- 天生的免疫反应对于早期感染控制至关重要.
- 自然杀手 (NK) 细胞是具有细胞毒性和细胞因子产生功能的先天性淋巴细胞.
- 淋巴细胞结构在脂肪组织免疫力中的作用基本上尚未被探索.
研究的目的:
- 为了识别和表征新的先天性淋巴细胞.
- 研究这些细胞在免疫反应中的功能.
- 探索脂肪相关淋巴群 (FALC) 在免疫中的作用.
主要方法:
- 在小鼠和人类的腹腔和中腔中发现了一种新的淋巴状结构 (FALC).
- 在FALC中独特的先天性淋巴细胞的表型特征 (Lin(-) c-Kit(+) Sca-1(+)).
- 评估细胞因子生产 (IL5,IL6,IL13) 和与B细胞支持和虫驱逐有关的功能测定.
主要成果:
- 发现FALC含有独特的先天性淋巴细胞 (Lin(-) c-Kit(+) Sca-1(+)) 与已知的淋巴原始细胞不同.
- 这些细胞在刺激时产生T(H) 2细胞因子 (IL5,IL6,IL13).
- 证明这些细胞支持B1细胞自我更新,增强IgA的产生,并在虫感染期间对IL13介导的杯状细胞增生至关重要.
结论:
- 鉴定出一种新的先天性淋巴细胞子集,称为"自然辅助细胞",存在于FALC.
- 自然辅助细胞对于T(H) 2型免疫反应至关重要,包括B细胞调节和虫驱逐.
- FALC代表了一个新的免疫利基,具有专门的先天性淋巴细胞,有助于粘膜免疫.
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