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Updated: May 2, 2026

An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C
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An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C

Published on: June 1, 2018

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实现多能性的重编程需要依赖AID的DNA脱甲基化

Nidhi Bhutani1, Jennifer J Brady, Mara Damian

  • 1Baxter Laboratory for Stem Cell Biology, Institute for Stem Cell Biology and Regenerative Medicine, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305-5175, USA.

Nature
|December 23, 2009
PubMed
概括

激活诱导的cytidine deaminase (AID) 通过去甲基化关键的多能性基因而驱动人类体细胞的快速,高效的重编程,使其成为诱导多能性干细胞 (iPS),而无需DNA复制.

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