细菌和古生物学的一个基因组学百科全书
Dongying Wu1, Philip Hugenholtz, Konstantinos Mavromatis
1DOE Joint Genome Institute, Walnut Creek, California 94598, USA.
Nature
|December 25, 2009
概括
基于进化关系而非仅仅生理学的微生物基因组测序提供了显著的优势. 这种基因组学方法增强了对微生物多样性和功能的理解.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
背景情况:
- 几乎有1000个细菌和古生物学基因组可用,但基于生理学的选择创造了一个有偏见的基因组学观点.
- 当前的基因组数据库缺乏多样化的基因组表征,限制了对微生物的全面理解.
研究的目的:
- 根据进化关系 (植物遗传学) 来调查选择微生物基因组进行测序的好处.
- 评估与随机基因组选择相比,基因组学方法的附加值.
主要方法:
- 测序和分析了56种可培养的细菌和古物种的基因组.
- 精选物种以最大限度地提高遗传学覆盖范围.
- 结果与现有数据库中随机选择的一组基因组进行了比较.
主要成果:
- 遗传学选择在重建进化历史方面产生了显著的好处.
- 有助于发现新型蛋白质家族和生物特性.
- 改善了对来自其他生物的已知基因的基因功能的预测.
结论:
- 基因组战略显著提高了从微生物基因组数据中获得的价值.
- 强烈支持系统的,以植物学为导向的努力,如"细菌和古生物的基因组百科全书".
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