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Updated: May 4, 2026

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
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Published on: August 11, 2017

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针对EGFR T790M的新型突变选择性EGFR激酶抑制剂

Wenjun Zhou1, Dalia Ercan, Liang Chen

  • 1Department of Cancer Biology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA.

Nature
|December 25, 2009
PubMed
概括

新的协同胺抑制剂在非小细胞肺癌中对EGFR T790M突变具有高强度,为现有治疗提供了潜在的替代方案,具有提高选择性和降低毒性.

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