银杏花用于预防老年人的认知衰退:一项随机试验
Beth E Snitz1, Ellen S O'Meara, Michelle C Carlson
1Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
JAMA
|December 31, 2009
概括
银杏花没有减缓老年人的认知衰退. 这项大型临床试验发现,服用银杏花提取物和服用安慰剂的人在认知衰老方面没有差异.
科学领域:
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
- 药理学 药理学 是一个学科.
背景情况:
- 银杏花是一种流行的草药补充剂,用于增强老年人群的认知健康.
- 缺乏足够的临床试验证据证明其对认知功能的长期影响.
研究的目的:
- 为了调查金科比洛巴提取物是否可以减缓老年人认知能力下降的速度.
- 评估对全球和特定领域认知功能的影响.
主要方法:
- 银杏记忆评估 (GEM) 研究是一项随机,双盲,安慰剂控制的试验.
- 3069名年龄在72-96岁之间的参与者每天两次接受120毫克金科比洛巴或安慰剂,平均时间为6.1年.
- 用修改的迷你精神状态检查 (3MSE),阿尔茨海默病评估量表 (ADAS-Cog) 和神经心理测试来测量认知衰退.
主要成果:
- 在所有测量领域中,Ginkgo biloba和安慰剂组之间没有观察到每年认知衰退率的显著差异.
- 3MSE和ADAS-Cog的变化率因基线认知状态而异,但没有显示治疗组差异.
- 治疗效果没有根据年龄,性别,种族,教育程度,APOE*E4等位基因状态或基线轻度认知障碍而有所不同.
结论:
- 在每天两次120毫克的剂量下,银杏花提取物没有显示出降低老年人认知能力下降的益处.
- 研究结果表明,金科比洛巴对于预防正常认知或轻度认知障碍的个体的认知衰退并不有效.
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