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Updated: Jun 17, 2026

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通过键替代物α-螺旋抑制低氧诱导的1-转录因子辅激剂相互作用

Laura K Henchey1, Swati Kushal, Ramin Dubey

  • 1Department of Chemistry, New York University, New York, New York 10003, USA.

Journal of the American Chemical Society
|January 1, 2010
PubMed
概括

研究人员设计了一种合成的α螺旋来抑制缺氧诱导基因表达. 这种分子破坏了关键蛋白相互作用,降低了像VEGF和GLUT1这样的基因的调节,为癌症研究和药物发现提供了潜力.

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