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Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease
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一种基结构组合策略,以创建强效和选择性的跨甲基素动力稳定剂,防止氨基代和细胞毒性

Sungwook Choi1, Natàlia Reixach, Stephen Connelly

  • 1Department of Chemistry, The Skaggs Institute for Chemical Biology, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|January 2, 2010
PubMed
概括

研究人员开发了新型的TTR动力稳定剂,以预防TTR聚合和相关的粉样蛋白疾病. 这些化合物稳定TTR,阻止神经退行并从细胞毒性影响中拯救细胞.

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...