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内源性红色素和心力衰竭的结果
Anne M S Belonje1, Adriaan A Voors, Peter van der Meer
1Departments of Cardiology, University Medical Center Groningen, Groningen, The Netherlands.
Circulation
|January 6, 2010
概括
心力衰竭 (HF) 患者血红素水平升高预测死亡风险增加. 在贫血患者中,持续高水平和较高的观察/预测红色素比率表明预后更差.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 内部医学 内部医学
背景情况:
- 升的内源性红色素在心力衰竭 (HF) 中很常见.
- 之前的研究表明,红色素水平与HF预后相关.
- 这项研究调查了红色素在大量高频队列中的临床和预后意义.
研究的目的:
- 在心力衰竭患者中评估红色素水平的预后价值.
- 为了检查红色素和血红蛋白水平之间的关系.
- 确定持续升高的红色素的预测力和死亡率的观察/预测比率.
主要方法:
- 在出院时和住院6个月的HF患者中测量了内源性红色素水平.
- 在贫血患者中计算了观察到/预测的红色素比率.
- 利用多变量考克斯回归分析来确定死亡率预测因素.
主要成果:
- 较高的基线红素水平独立预测了18个月死亡率的增加 (HR 2.06).
- 持续升高的红色素水平 (在两个时间点均高于中位数) 与较高的死亡风险有关 (HR 2.24).
- 在贫血患者中,较高的观察/预测红色素比率与死亡率的增加有关 (HR 3.52).
结论:
- 红素水平是心力衰竭死亡率的显著预测因素.
- 持续升高的红色素水平具有独立的预后价值.
- 在贫血的HF患者中观察到/预测的较高的红色素比率可能表明死亡风险增加.
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