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Updated: Jun 17, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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对于Cryptosporidium特定的IMP脱酶抑制剂选择性的结构基础

Iain S Macpherson1, Sivapriya Kirubakaran, Suresh Kumar Gorla

  • 1Departments of Biology, Brandeis University, MS009, 415 South Street, Waltham, Massachusetts 02454, USA.

Journal of the American Chemical Society
|January 8, 2010
PubMed
概括

对于Cryptosporidium parvum感染,目前还没有有效的治疗方法. 研究人员确定了寄生虫的IMPDH酶的晶体结构,从而使潜在的药物疗法的高度选择性抑制剂的开发成为可能.

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